Biomedical Research: As a cell-permeable AMPK (adenosine monophosphate protein kinase) activator, it simulates exercise, regulates lipid and glucose metabolism, inhibits anabolic processes, and is used to study cellular energy metabolism, mitochondrial autophagy and related signaling pathways. Pharmaceutical Field: Used as a pharmaceutical intermediate for the research and development of drugs for treating acute lymphocyte leukemia, myocardial ischemia, acute kidney injury and other diseases;
Product Name: AICAR
Alias: Acadesine; AICA Riboside; 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; 5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide; NSC 105823; MFCD00869751; PubChem: 24724407
CAS No.: 2627-69-2
EINECS No.: 220-097-5
Molecular Formula:C₉H₁₄N₄O₅
Molecular Weight: 258.23 g/mol
Classification: Organic compound, nucleoside analog, AMPK activator, pharmaceutical intermediate, research reagent, biochemical reagent, purine nucleoside derivative
Appearance: Tan crystalline powder, odorless; stable under proper storage conditions, slightly hygroscopic; mild skin/eye irritation on prolonged contact; TSCA listed.
Density: 2.06±0.1 g/cm3 (25℃, predicted); LogP: -2.2; PSA: 157; pKa: 13.27±0.70 (predicted); maximum wavelength (λmax): 265nm (NaOH, lit.).
Melting Point: 214-215℃ (lit.), stable at room temperature.
Boiling Point: 726.3±60.0℃ (predicted), decomposes before boiling at atmospheric pressure.
Solubility: Soluble in water (>10 mg/mL at 20℃); soluble in DMSO (2 mg/mL); slightly soluble in ethanol (<1 mg/mL); insoluble in non-polar organic solvents.
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